State of the Art Management of Acute Pulmonary Embolism

Authors

  • Eyadeh Mdanat Cayuga Medical Center
  • Armita Kabirpour The Mount Sinai Hospital
  • Erick Sun The Mount Sinai Hospital
  • Sophia Alexis The Mount Sinai Hospital
  • John Puskas The Mount Sinai Hospital
  • Omar Lattouf Emory University School of Medicine

DOI:

https://doi.org/10.58877/japaj.v1i3.72

Abstract

The desire for surgical intervention for pulmonary embolism (PE) precipitated the development of cardiopulmonary bypass, and therefore a new era in history of cardiac surgery, cardiology, and medicine. However, the advent of systemic thrombolysis and catheter-directed therapy have decreased interest in surgical management of PE. Surgical pulmonary embolectomy is limited to patients in critical condition with high mortality after other interventions have failed. The issue with clinicians delaying surgical pulmonary embolectomy is that in the interim patients may become critically ill with irreversible end organ dysfunction. Management necessitates decompression of RV afterload by relieving PE obstruction to improve RV function and left ventricular filling. Understanding the pathophysiology of right ventricular outflow tract (RVOT) obstruction and RV failure with a multidisciplinary heart team is paramount.

References

Trendelenburg F. Operative Management of Pulmonary Emboli. Arch Klin Chir, 1908;86:686-700.

Ochsner A. History of thoracic surgery. Surg Clin N Am. 1966;46:1355–1376. DOI: https://doi.org/10.1016/S0039-6109(16)38076-8

Steenburg RW, Warren R, Wilson RE, Rudolf LE. A new look at pulmonary embolectomy. Surg Gynecol Obstet. 1958;107(2):214-20.

Meyer JA, Trendelenburg F. The surgical approach to massive pulmonary embolism. Arch Surg. 1990;125(9):1202-5. DOI: https://doi.org/10.1001/archsurg.1990.01410210128020

Gibbon JH, Jr. Artificial maintenance of circulation during experimental occlusion of pulmonary artery. Arch Surg. 1937;34(6):1105-31. DOI: https://doi.org/10.1001/archsurg.1937.01190120131008

Sharp EH. Pulmonary embolectomy: successful removal of a massive pulmonary embolus with the support of cardiopulmonary bypass. Case report. Ann surg. 1962;156(1):1-4. DOI: https://doi.org/10.1097/00000658-196207000-00001

Cooley DA, Beall AC, Jr., Alexander JK. Acute Massive Pulmonary Embolism: Successful Surgical Treatment Using Temporary Cardiopulmonary Bypass. JAMA. 1961;177(5):283-6. DOI: https://doi.org/10.1001/jama.1961.03040310001001

Kalra R, Bajaj N, Ather S, et al. Mortality outcomes for surgical pulmonary

embolectomy for high-risk pulmonary embolism: A comprehensive meta-

analysis.. J Am Coll Cardiol. 2016 Apr, 67 (13_Supplement)

Goldhaber SZ. Surgical pulmonary embolectomy: the resurrection of an almost discarded operation. Tex Heart Inst J. 2013;40(1):5-8.

Gulba DC, Schmid C, Borst HG, Lichtlen P, Dietz R, Luft FC. Medical compared with surgical treatment for massive pulmonary embolism. Lancet. 1994;343(8897):576-7. DOI: https://doi.org/10.1016/S0140-6736(94)91523-7

Takahashi H, Okada K, Matsumori M, Kano H, Kitagawa A, Okita Y. Aggressive surgical treatment of acute pulmonary embolism with circulatory collapse. Ann Thorac Surg. 2012;94(3):785-91. DOI: https://doi.org/10.1016/j.athoracsur.2012.03.101

Poterucha TJ, Bergmark B, Aranki S, Kaneko T, Piazza G. Surgical Pulmonary Embolectomy. Circulation. 2015;132(12):1146-51. DOI: https://doi.org/10.1161/CIRCULATIONAHA.115.015916

Raskob GE, Angchaisuksiri P, Blanco AN, Buller H, Gallus A, Hunt BJ, et al. Thrombosis: a major contributor to global disease burden. Arterioscler Thromb Vasc Biol. 2014;34(11):2363-71. DOI: https://doi.org/10.1161/ATVBAHA.114.304488

Goldhaber SZ. Pulmonary embolism. Lancet. 2004;363(9417):1295-305. DOI: https://doi.org/10.1016/S0140-6736(04)16004-2

Kasper W, Konstantinides S, Geibel A, et al. Management Strategies and Determinants of Outcome in Acute Major Pulmonary Embolism: Results of a Multicenter Registry. JACC. 1997;30(5):1165-71. DOI: https://doi.org/10.1016/S0735-1097(97)00319-7

Jaff MR, McMurtry MS, Archer SL, et al. Management of Massive and Submassive Pulmonary Embolism, Iliofemoral Deep Vein Thrombosis, and Chronic Thromboembolic Pulmonary Hypertension. Circulation. 2011;123(16):1788-830.

Kabrhel C, Rempell JS, Avery LL, Dudzinski DM, Weinberg I. Case 29-2014. N Engl J Med. 2014;371(12):1143-50. DOI: https://doi.org/10.1056/NEJMcpc1403307

Jiménez D, Aujesky D, Moores L, et al. Simplification of the Pulmonary Embolism Severity Index for Prognostication in Patients With Acute Symptomatic Pulmonary Embolism. Arch Intern Med. 2010;170(15):1383-9. DOI: https://doi.org/10.1001/archinternmed.2010.199

Konstantinides SV, Meyer G, Becattini C, et al. 2019 ESC Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS): The Task Force for the diagnosis and management of acute pulmonary embolism of the European Society of Cardiology (ESC). Eur Heart J. 2020;41(4):543-603. DOI: https://doi.org/10.1093/eurheartj/ehz405

Greelish JP, Leacche M, Solenkova NS, Ahmad RM, Byrne JG. Improved midterm outcomes for type A (central) pulmonary emboli treated surgically. J Thorac Cardiovasc Surg. 2011;142(6):1423-9. DOI: https://doi.org/10.1016/j.jtcvs.2010.12.030

Grosse SD, Nelson RE, Nyarko KA, Richardson LC, Raskob GE. The economic burden of incident venous thromboembolism in the United States: A review of estimated attributable healthcare costs. Thromb Res. 2016;137:3-10. DOI: https://doi.org/10.1016/j.thromres.2015.11.033

Rivera-Lebron B, McDaniel M, Ahrar K, Alrifai A, Dudzinski DM, Fanola C, et al. Diagnosis, Treatment and Follow Up of Acute Pulmonary Embolism: Consensus Practice from the PERT Consortium. Clin Appl Thromb Hemost. 2019;25:1076029619853037. DOI: https://doi.org/10.1177/1076029619853037

Deitelzweig SB, Johnson BH, Lin J, Schulman KL. Prevalence of clinical venous thromboembolism in the USA: current trends and future projections. Am J Hematol. 2011;86(2):217-20. DOI: https://doi.org/10.1002/ajh.21917

Kakkar VV, Howe CT, Flanc C, Clarke MB. Natural history of postoperative deep-vein thrombosis. Lancet. 1969;2(7614):230-2. DOI: https://doi.org/10.1016/S0140-6736(69)90002-6

Guérin L, Couturaud F, Parent F, et al. Prevalence of chronic thromboembolic pulmonary hypertension after acute pulmonary embolism. Prevalence of CTEPH after pulmonary embolism. Thromb Hemost. 2014;112(3):598-605. DOI: https://doi.org/10.1160/TH13-07-0538

Lang IM, Pesavento R, Bonderman D, Yuan JX-J. Risk factors and basic mechanisms of chronic thromboembolic pulmonary hypertension: a current understanding. Eur Respir J. 2013;41(2):462-8. DOI: https://doi.org/10.1183/09031936.00049312

Anderson FA, Spencer FA. Risk Factors for Venous Thromboembolism. Circulation. 2003;107(23_suppl_1):I-9-I-16. DOI: https://doi.org/10.1161/01.CIR.0000078469.07362.E6

Lapostolle F, Surget V, Borron SW, Desmaizières M, Sordelet D, Lapandry C, et al. Severe Pulmonary Embolism Associated with Air Travel. N Engl J Med. 2001;345(11):779-83. DOI: https://doi.org/10.1056/NEJMoa010378

Goldhaber SZ, Grodstein F, Stampfer MJ, et al. A Prospective Study of Risk Factors for Pulmonary Embolism in Women. JAMA. 1997;277(8):642-5. DOI: https://doi.org/10.1001/jama.277.8.642

Blokhin IO, Lentz SR. Mechanisms of thrombosis in obesity. Curr Opin Hematol. 2013;20(5):437-444. doi:10.1097/MOH.0b013e3283634443. DOI: https://doi.org/10.1097/MOH.0b013e3283634443

Rosing J, Middeldorp S, Curvers J, Christella M, Thomassen LG, Nicolaes GA, et al. Low-dose oral contraceptives and acquired resistance to activated protein C: a randomised cross-over study. Lancet. 1999;354(9195):2036-40. DOI: https://doi.org/10.1016/S0140-6736(99)06092-4

Nelson HD, Humphrey LL, Nygren P, Teutsch SM, Allan JD. Postmenopausal hormone replacement therapy: scientific review. JAMA. 2002;288(7):872-81. DOI: https://doi.org/10.1001/jama.288.7.872

Greer IA. Thrombosis in pregnancy: maternal and fetal issues. Lancet. 1999;353(9160):1258-65. DOI: https://doi.org/10.1016/S0140-6736(98)10265-9

Cummings SR, Eckert S, Krueger KA, Grady D, Powles TJ, Cauley JA, et al. The effect of raloxifene on risk of breast cancer in postmenopausal women: results from the MORE randomized trial. Multiple Outcomes of Raloxifene Evaluation. JAMA. 1999;281(23):2189-97. DOI: https://doi.org/10.1001/jama.281.23.2189

Schulman S, Lindmarker P. Incidence of cancer after prophylaxis with warfarin against recurrent venous thromboembolism. Duration of Anticoagulation Trial. N Engl J Med. 2000;342(26):1953-8. DOI: https://doi.org/10.1056/NEJM200006293422604

Sørensen HT, Mellemkjaer L, Olsen JH, Baron JA. Prognosis of cancers associated with venous thromboembolism. N Engl J Med. 2000;343(25):1846-50. DOI: https://doi.org/10.1056/NEJM200012213432504

Prandoni P, Lensing AWA, Büller HR, et al. Deep-Vein Thrombosis and the Incidence of Subsequent Symptomatic Cancer. N Engl J Med. 1992;327(16):1128-33. DOI: https://doi.org/10.1056/NEJM199210153271604

Huber O, Bounameaux H, Borst F, Rohner A. Postoperative pulmonary embolism after hospital discharge. An underestimated risk. Arch Surg. 1992;127(3):310-3. DOI: https://doi.org/10.1001/archsurg.1992.01420030076014

Hyers TM. Venous thromboembolism. Am J Respir Crit Care Med. 1999;159(1):1-14. DOI: https://doi.org/10.1164/ajrccm.159.1.9803109

Bertina RM, Koeleman BP, Koster T, et al. Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature. 1994;369(6475):64-7. DOI: https://doi.org/10.1038/369064a0

Bloemenkamp KW, Rosendaal FR, Helmerhorst FM, Büller HR, Vandenbroucke JP. Enhancement by factor V Leiden mutation of risk of deep-vein thrombosis associated with oral contraceptives containing a third-generation progestagen. Lancet. 1995;346(8990):1593-6. DOI: https://doi.org/10.1016/S0140-6736(95)91929-5

Levine JS, Branch DW, Rauch J. The Antiphospholipid Syndrome. N Engl J Med. 2002;346(10):752-63. DOI: https://doi.org/10.1056/NEJMra002974

Hankey GJ, Eikelboom JW. Homocysteine and vascular disease. Lancet. 1999;354(9176):407-13. DOI: https://doi.org/10.1016/S0140-6736(98)11058-9

Stratmann G, Gregory GA. Neurogenic and humoral vasoconstriction in acute pulmonary thromboembolism. Anesth Analg. 2003;97(2):341-54. DOI: https://doi.org/10.1213/01.ANE.0000068983.18131.F0

McIntyre KM, Sasahara AA. The hemodynamic response to pulmonary embolism in patients without prior cardiopulmonary disease. Am J Cardiol. 1971;28(3):288-94. DOI: https://doi.org/10.1016/0002-9149(71)90116-0

Orde MM, Puranik R, Morrow PL, Duflou J. Myocardial pathology in pulmonary thromboembolism. Heart. 2011;97(20):1695-9. DOI: https://doi.org/10.1136/hrt.2011.226209

Furlan A, Aghayev A, Chang CC, Patil A, Jeon KN, Park B, et al. Short-term mortality in acute pulmonary embolism: clot burden and signs of right heart dysfunction at CT pulmonary angiography. Radiology. 2012;265(1):283-93. DOI: https://doi.org/10.1148/radiol.12110802

Apfaltrer P, Bachmann V, Meyer M, Henzler T, Barraza JM, Gruettner J, et al. Prognostic value of perfusion defect volume at dual energy CTA in patients with pulmonary embolism: correlation with CTA obstruction scores, CT parameters of right ventricular dysfunction and adverse clinical outcome. Eur J Radiol. 2012;81(11):3592-7. DOI: https://doi.org/10.1016/j.ejrad.2012.02.008

Vedovati MC, Becattini C, Agnelli G, Kamphuisen PW, Masotti L, Pruszczyk P, et al. Multidetector CT scan for acute pulmonary embolism: embolic burden and clinical outcome. Chest. 2012;142(6):1417-24. DOI: https://doi.org/10.1378/chest.11-2739

Ribeiro A, Lindmarker P, Juhlin-Dannfelt A, Johnsson H, Jorfeldt L. Echocardiography Doppler in pulmonary embolism: Right ventricular dysfunction as a predictor of mortality rate. Am Heart J. 1997;134(3):479-87. DOI: https://doi.org/10.1016/S0002-8703(97)70085-1

Torbicki A, Perrier A, Konstantinides S, et al. Guidelines on the diagnosis and management of acute pulmonary embolism: the Task Force for the Diagnosis and Management of Acute Pulmonary Embolism of the European Society of Cardiology (ESC). Eur Heart J. 2008;29(18):2276-315. DOI: https://doi.org/10.1093/eurheartj/ehn310

Tapson VF. Acute Pulmonary Embolism. N Engl J Med. 2008;358(10):1037-52. DOI: https://doi.org/10.1056/NEJMra072753

Blann AD, Lip GY. Venous thromboembolism. Brit Med J. 2006;332(7535):215-9. DOI: https://doi.org/10.1136/bmj.332.7535.215

Le Gal G, Righini M, Parent F, van Strijen M, Couturaud F. Diagnosis and management of subsegmental pulmonary embolism. J Thromb Haemost. 2006;4(4):724-31. DOI: https://doi.org/10.1111/j.1538-7836.2006.01819.x

Wicki J, Perrier A, Perneger TV, Bounameaux H, Junod AF. Predicting adverse outcome in patients with acute pulmonary embolism: a risk score. Thromb Haemost. 2000;84(4):548-52. DOI: https://doi.org/10.1055/s-0037-1614065

Raja AS, Greenberg JO, Qaseem A, Denberg TD, Fitterman N, Schuur JD. Evaluation of Patients With Suspected Acute Pulmonary Embolism: Best Practice Advice From the Clinical Guidelines Committee of the American College of Physicians. Ann Intern Med. 2015;163(9):701-11. DOI: https://doi.org/10.7326/M14-1772

Konstantinides SV, Torbicki A, Agnelli G, et al. 2014 ESC Guidelines on the diagnosis and management of acute pulmonary embolism: The Task Force for the Diagnosis and Management of Acute Pulmonary Embolism of the European Society of Cardiology (ESC)Endorsed by the European Respiratory Society (ERS). Eur Heart J. 2014;35(43):3033-80. DOI: https://doi.org/10.1093/eurheartj/ehu283

Kline JA, Mitchell AM, Kabrhel C, Richman PB, Courtney DM. Clinical criteria to prevent unnecessary diagnostic testing in emergency department patients with suspected pulmonary embolism. J Thromb Haemost. 2004;2(8):1247-55. DOI: https://doi.org/10.1111/j.1538-7836.2004.00790.x

Streiff MB, Agnelli G, Connors JM, et al. Guidance for the treatment of deep vein thrombosis and pulmonary embolism. J Thromb Thrombolysis. 2016;41(1):32-67. DOI: https://doi.org/10.1007/s11239-015-1317-0

Vanni S, Jiménez D, Nazerian P, et al. Short-term clinical outcome of normotensive patients with acute PE and high plasma lactate. Thorax. 2015;70(4):333-8. DOI: https://doi.org/10.1136/thoraxjnl-2014-206300

Coutance G, Cauderlier E, Ehtisham J, Hamon M, Hamon M. The prognostic value of markers of right ventricular dysfunction in pulmonary embolism: a meta-analysis. Crit Care. 2011;15(2):R103. DOI: https://doi.org/10.1186/cc10119

Becattini C, Vedovati MC, Agnelli G. Prognostic value of troponins in acute pulmonary embolism: a meta-analysis. Circulation. 2007;116(4):427-33. DOI: https://doi.org/10.1161/CIRCULATIONAHA.106.680421

Ayaram D, Bellolio MF, Murad MH, et al. Triple rule-out computed tomographic angiography for chest pain: a diagnostic systematic review and meta-analysis. Acad Emerg Med. 2013;20(9):861-71. DOI: https://doi.org/10.1111/acem.12210

Wittram C. How I do it: CT pulmonary angiography. AJR Am J Roentgenol. 2007;188(5):1255-61. DOI: https://doi.org/10.2214/AJR.06.1104

Wiener RS, Schwartz LM, Woloshin S. Time trends in pulmonary embolism in the United States: evidence of overdiagnosis. Arch Intern Med. 2011;171(9):831-7. DOI: https://doi.org/10.1001/archinternmed.2011.178

Grifoni S, Olivotto I, Cecchini P, et al. Short-term clinical outcome of patients with acute pulmonary embolism, normal blood pressure, and echocardiographic right ventricular dysfunction. Circulation. 2000;101(24):2817-22. DOI: https://doi.org/10.1161/01.CIR.101.24.2817

Wolde M, Söhne M, Quak E, Mac Gillavry MR, Büller HR. Prognostic value of echocardiographically assessed right ventricular dysfunction in patients with pulmonary embolism. Arch Intern Med. 2004;164(15):1685-9. DOI: https://doi.org/10.1001/archinte.164.15.1685

Stawicki SP, Seamon MJ, Meredith DM, et al. Transthoracic echocardiography for suspected pulmonary embolism in the intensive care unit: unjustly underused or rightfully ignored? J Clin Ultrasound. 2008;36(5):291-302. DOI: https://doi.org/10.1002/jcu.20461

Miniati M, Monti S, Pratali L, et al. Value of transthoracic echocardiography in the diagnosis of pulmonary embolism: results of a prospective study in unselected patients. Am J Med. 2001;110(7):528-35. DOI: https://doi.org/10.1016/S0002-9343(01)00693-3

Stein PD, Athanasoulis C, Alavi A, et al. Complications and validity of pulmonary angiography in acute pulmonary embolism. Circulation. 1992;85(2):462-8. DOI: https://doi.org/10.1161/01.CIR.85.2.462

Klok FA, Huisman MV. Epidemiology and management of chronic thromboembolic pulmonary hypertension. Neth J Med. 2010;68(9):347-51.

van Beek EJ, Brouwerst EM, Song B, Stein PD, Oudkerk M. Clinical validity of a normal pulmonary angiogram in patients with suspected pulmonary embolism--a critical review. Clin Radiol. 2001;56(10):838-42. DOI: https://doi.org/10.1053/crad.2001.0778

Reinartz P, Wildberger JE, Schaefer W, Nowak B, Mahnken AH, Buell U. Tomographic imaging in the diagnosis of pulmonary embolism: a comparison between V/Q lung scintigraphy in SPECT technique and multislice spiral CT. J Nucl Med. 2004;45(9):1501-8.

Oudkerk M, van Beek EJ, Wielopolski P, et al. Comparison of contrast-enhanced magnetic resonance angiography and conventional pulmonary angiography for the diagnosis of pulmonary embolism: a prospective study. Lancet. 2002;359(9318):1643-7. DOI: https://doi.org/10.1016/S0140-6736(02)08596-3

Stein PD, Chenevert TL, Fowler SE, et al. Gadolinium-enhanced magnetic resonance angiography for pulmonary embolism: a multicenter prospective study (PIOPED III). Ann Intern Med. 2010;152(7):434-43, w142-3. DOI: https://doi.org/10.7326/0003-4819-152-7-201004060-00008

Sostman HD, Jablonski KA, Woodard PK, et al. Factors in the technical quality of gadolinium enhanced magnetic resonance angiography for pulmonary embolism in PIOPED III. Int J Cardiovasc Imaging. 2012;28(2):303-12. DOI: https://doi.org/10.1007/s10554-011-9820-7

Revel MP, Sanchez O, Couchon S, et al. Diagnostic accuracy of magnetic resonance imaging for an acute pulmonary embolism: results of the 'IRM-EP' study. J Thromb Haemost. 2012;10(5):743-50. DOI: https://doi.org/10.1111/j.1538-7836.2012.04652.x

Dudzinski DM, Piazza G. Multidisciplinary Pulmonary Embolism Response Teams. Circulation. 2016;133(1):98-103. DOI: https://doi.org/10.1161/CIRCULATIONAHA.115.015086

Jaff MR, McMurtry MS, Archer SL, et al. Management of massive and submassive pulmonary embolism, iliofemoral deep vein thrombosis, and chronic thromboembolic pulmonary hypertension: a scientific statement from the American Heart Association. Circulation. 2011;123(16):1788-830. DOI: https://doi.org/10.1161/CIR.0b013e318214914f

Kearon C, Akl EA, Comerota AJ, et al. Antithrombotic therapy for VTE disease: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012;141(2 Suppl):e419S-e96S.

Bĕlohlávek J, Dytrych V, Linhart A. Pulmonary embolism, part I: Epidemiology, risk factors and risk stratification, pathophysiology, clinical presentation, diagnosis and nonthrombotic pulmonary embolism. Exp Clin Cardiol. 2013;18(2):129-38.

Fihn SD, Blankenship JC, Alexander KP, et al. 2014 ACC/AHA/AATS/PCNA/SCAI/STS Focused Update of the Guideline for the Diagnosis and Management of Patients With Stable Ischemic Heart Disease. Circulation. 2014;130(19):1749-67. DOI: https://doi.org/10.1161/CIR.0000000000000095

Swain S, Turner C, Tyrrell P, Rudd A. Diagnosis and initial management of acute stroke and transient ischemic attack: summary of NICE guidance. Bmj. 2008;337:a786. DOI: https://doi.org/10.1136/bmj.a786

Jauch EC, Saver JL, Adams HP, et al. Guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2013;44(3):870-947. DOI: https://doi.org/10.1161/STR.0b013e318284056a

Condliffe R, Elliot CA, Hughes RJ, et al. Management dilemmas in acute pulmonary embolism. Thorax. 2014;69(2):174-80. DOI: https://doi.org/10.1136/thoraxjnl-2013-204667

Kubitza D, Becka M, Voith B, Zuehlsdorf M, Wensing G. Safety, pharmacodynamics, and pharmacokinetics of single doses of BAY 59-7939, an oral, direct factor Xa inhibitor. Clin Pharmacol Ther. 2005;78(4):412-21. DOI: https://doi.org/10.1016/j.clpt.2005.06.011

Raghavan N, Frost CE, Yu Z, et al. Apixaban Metabolism and Pharmacokinetics after Oral Administration to Humans. Drug Metabolism and Disposition. 2009;37(1):74-81. DOI: https://doi.org/10.1124/dmd.108.023143

Ahrens I, Bode C. Oral anticoagulation with edoxaban. Focus on current phase III clinical development. Hamostaseologie. 2012;32(3):212-5. DOI: https://doi.org/10.5482/HAMO-12-05-0004

Camm AJ, Bounameaux H. Edoxaban: a new oral direct factor xa inhibitor. Drugs. 2011;71(12):1503-26. DOI: https://doi.org/10.2165/11595540-000000000-00000

Sorbera L, Bozzo J, Castañer J. Dabigatran/Dabigatran etexilate. Drugs Future. 2005;30:877. DOI: https://doi.org/10.1358/dof.2005.030.09.938760

Stangier J, Eriksson BI, Dahl OE, et al. Pharmacokinetic profile of the oral direct thrombin inhibitor dabigatran etexilate in healthy volunteers and patients undergoing total hip replacement. J Clin Pharmacol. 2005;45(5):555-63. DOI: https://doi.org/10.1177/0091270005274550

Walenga JM, Adiguzel C. Drug and dietary interactions of the new and emerging oral anticoagulants. Int J Clin Pract. 2010;64(7):956-67. DOI: https://doi.org/10.1111/j.1742-1241.2009.02286.x

Schulman S, Kakkar AK, Goldhaber SZ, et al. Treatment of acute venous thromboembolism with dabigatran or warfarin and pooled analysis. Circulation. 2014;129(7):764-72. DOI: https://doi.org/10.1161/CIRCULATIONAHA.113.004450

The Hokusai-VTE Investigators. Edoxaban versus warfarin for the treatment of symptomatic venous thromboembolism. N Engl J Med. 2013;369:1406-15. DOI: 10.1056/NEJMoa1306638. DOI: https://doi.org/10.1056/NEJMoa1306638

Agnelli G, Buller HR, Cohen A, et al. Oral Apixaban for the Treatment of Acute Venous Thromboembolism. N Engl J Med. 2013;369(9):799-808. DOI: https://doi.org/10.1056/NEJMoa1302507

Bauersachs R, Berkowitz S, Brenner B, et al. Oral Rivaroxaban for Symptomatic Venous Thromboembolism. N Engl J Med. 2010;363:2499-510. DOI: https://doi.org/10.1056/NEJMoa1007903

Büller HR, Prins MH, Lensin AW, et al. Oral rivaroxaban for the treatment of symptomatic pulmonary embolism. N Engl J Med. 2012;366(14):1287-97. DOI: https://doi.org/10.1056/NEJMoa1113572

Ramagopalan SV, Carroll R, Ulvestad M, Mehmud F, Alikhan R. The changing face of venous thromboembolism management in England. Future Cardiol. 2019;15(3):183-5. DOI: https://doi.org/10.2217/fca-2019-0003

Goldhaber SZ, Visani L, De Rosa M. Acute pulmonary embolism: clinical outcomes in the International Cooperative Pulmonary Embolism Registry (ICOPER). Lancet. 1999;353(9162):1386-9. DOI: https://doi.org/10.1016/S0140-6736(98)07534-5

Konstantinides S, Geibel A, Heusel G, Heinrich F, Kasper W. Heparin plus Alteplase Compared with Heparin Alone in Patients with Submassive Pulmonary Embolism. N Engl J Med. 2002;347(15):1143-50. DOI: https://doi.org/10.1056/NEJMoa021274

Meyer G, Vicaut E, Danays T, et al. Fibrinolysis for Patients with Intermediate-Risk Pulmonary Embolism. N Engl J Med. 2014;370(15):1402-11. DOI: https://doi.org/10.1056/NEJMoa1302097

Marti C, John G, Konstantinides S, et al. Systemic thrombolytic therapy for acute pulmonary embolism: a systematic review and meta-analysis. Eur Heart J. 2015;36(10):605-14. DOI: https://doi.org/10.1093/eurheartj/ehu218

Chatterjee S, Chakraborty A, Weinberg I, et al. Thrombolysis for pulmonary embolism and risk of all-cause mortality, major bleeding, and intracranial hemorrhage: a meta-analysis. JAMA. 2014;311(23):2414-21. DOI: https://doi.org/10.1001/jama.2014.5990

Nakamura S, Takano H, Kubota Y, Asai K, Shimizu W. Impact of the efficacy of thrombolytic therapy on the mortality of patients with acute submassive pulmonary embolism: a meta-analysis. J Thromb Haemost. 2014;12(7):1086-95. DOI: https://doi.org/10.1111/jth.12608

Kline JA, Nordenholz KE, Courtney DM, et al. Treatment of submassive pulmonary embolism with tenecteplase or placebo: cardiopulmonary outcomes at 3 months: multicenter double-blind, placebo-controlled randomized trial. J Thromb Haemost. 2014;12(4):459-68. DOI: https://doi.org/10.1111/jth.12521

Riera-Mestre A, Jiménez D, Muriel A, et al. Thrombolytic therapy and outcome of patients with an acute symptomatic pulmonary embolism. J Thromb Haemost. 2012;10(5):751-9. DOI: https://doi.org/10.1111/j.1538-7836.2012.04698.x

Iskander A, Nayak A, Chauhan MS. Submassive pulmonary embolism and paradoxical embolic stroke treated with percutaneous rheolytic thrombectomy and closure of the patent foramen ovale. Catheter Cardiovasc Interv. 2005;64(3):356-60. DOI: https://doi.org/10.1002/ccd.20306

Pavesi PC, Pedone C, Crisci M, Piacentini A, Fulvi M, Di Pasquale G. Concomitant submassive pulmonary embolism and paradoxical embolic stroke after a long flight: which is the optimal treatment? J Cardiovasc Med. 2008;9(10):1070-3. DOI: https://doi.org/10.2459/JCM.0b013e328306f2ea

Sharifi M, Bay C, Skrocki L, Rahimi F, Mehdipour M. Moderate Pulmonary Embolism Treated With Thrombolysis (from the “MOPETT” Trial). Am J Card. 2013;111(2):273-7. DOI: https://doi.org/10.1016/j.amjcard.2012.09.027

Kline JA, Steuerwald MT, Marchick MR, Hernandez-Nino J, Rose GA. Prospective evaluation of right ventricular function and functional status 6 months after acute submassive pulmonary embolism: frequency of persistent or subsequent elevation in estimated pulmonary artery pressure. Chest. 2009;136(5):1202-10. DOI: https://doi.org/10.1378/chest.08-2988

Stevinson BG, Hernandez-Nino J, Rose G, Kline JA. Echocardiographic and functional cardiopulmonary problems 6 months after first-time pulmonary embolism in previously healthy patients. Eur Heart J. 2007;28(20):2517-24. DOI: https://doi.org/10.1093/eurheartj/ehm295

Pengo V, Lensing AW, Prins MH, et al. Incidence of chronic thromboembolic pulmonary hypertension after pulmonary embolism. N Engl J Med. 2004;350(22):2257-64. DOI: https://doi.org/10.1056/NEJMoa032274

Sista AK, Kuo WT, Schiebler M, Madoff DC. Stratification, Imaging, and Management of Acute Massive and Submassive Pulmonary Embolism. Radiology. 2017;284(1):5-24. DOI: https://doi.org/10.1148/radiol.2017151978

Wang C, Zhai Z, Yang Y, et al. Efficacy and Safety of Low Dose Recombinant Tissue-Type Plasminogen Activator for the Treatment of Acute Pulmonary Thromboembolism: A Randomized, Multicenter, Controlled Trial. Chest. 2010;137(2):254-62. DOI: https://doi.org/10.1378/chest.09-0765

Armstrong PW, Gershlick AH, Goldstein P, et al. Fibrinolysis or Primary PCI in ST-Segment Elevation Myocardial Infarction. N Engl J Med. 2013;368(15):1379-87. DOI: https://doi.org/10.1056/NEJMoa1301092

Lumsden AB, Suarez E. Interventional Therapy for Pulmonary Embolism. Methodist Debakey Cardiovasc J. 2016;12(4):219-24. DOI: https://doi.org/10.14797/mdcj-12-4-219

Engelberger RP, Kucher N. Ultrasound-assisted thrombolysis for acute pulmonary embolism: a systematic review. Eur Heart J. 2014;35(12):758-64. DOI: https://doi.org/10.1093/eurheartj/ehu029

Kuo WT, Gould MK, Louie JD, Rosenberg JK, Sze DY, Hofmann LV. Catheter-directed therapy for the treatment of massive pulmonary embolism: systematic review and meta-analysis of modern techniques. J Vasc Interv Radiol. 2009;20(11):1431-40. DOI: https://doi.org/10.1016/j.jvir.2009.08.002

Kucher N, Boekstegers P, Müller OJ, Kupatt C, Beyer-Westendorf J, Heitzer T, et al. Randomized, Controlled Trial of Ultrasound-Assisted Catheter-Directed Thrombolysis for Acute Intermediate-Risk Pulmonary Embolism. Circulation. 2014;129(4):479-86. DOI: https://doi.org/10.1161/CIRCULATIONAHA.113.005544

Braaten JV, Goss RA, Francis CW. Ultrasound reversibly disaggregates fibrin fibers. Thromb Haemost. 1997;78(3):1063-8. DOI: https://doi.org/10.1055/s-0038-1657688

Donaldson CW, Baker JN, Narayan RL, et al. Thrombectomy using suction filtration and veno-venous bypass: single center experience with a novel device. Catheter Cardiovasc Interv. 2015;86(2):E81-7. DOI: https://doi.org/10.1002/ccd.25583

Jaber WA, Fong PP, Weisz G, et al. Acute pulmonary embolism: with an emphasis on an interventional approach. JAMA. 2016;67(8):991-1002. DOI: https://doi.org/10.1016/j.jacc.2015.12.024

Rocek M, Peregrin J, Velimsky T. Mechanical thrombectomy of massive pulmonary embolism using an Arrow-Trerotola percutaneous thrombolytic device. Eur Radiol. 1998;8(9):1683-5. DOI: https://doi.org/10.1007/s003300050613

Barjaktarevic I, Friedman O, Ishak C, Sista AK. Catheter-directed clot fragmentation using the Cleaner™ device in a patient presenting with massive pulmonary embolism. J Radiol Case Rep. 2014;8(2):30-6. DOI: https://doi.org/10.3941/jrcr.v8i2.1455

Dumantepe M, Teymen B, Akturk U, Seren M. Efficacy of rotational thrombectomy on the mortality of patients with massive and submassive pulmonary embolism. J Card Surg. 2015;30(4):324-32. DOI: https://doi.org/10.1111/jocs.12521

Patel AR, Patel AR, Singh S, Singh S, Khawaja I. Applied uses of extracorporeal membrane oxygenation therapy. Cureus. 2019;11(7):e5163. DOI: https://doi.org/10.7759/cureus.5163

Cheung AW, White CW, Davis MK, Freed DH. Short-term mechanical circulatory support for recovery from acute right ventricular failure: clinical outcomes. J heart lung Transplant. 2014;33(8):794-9. DOI: https://doi.org/10.1016/j.healun.2014.02.028

Pasrija C, Kronfli A, George P, et al. Utilization of veno-arterial extracorporeal membrane oxygenation for massive pulmonary embolism. Ann Thorac Surg. 2018;105(2):498-504. DOI: https://doi.org/10.1016/j.athoracsur.2017.08.033

Aymard T, Kadner A, Widmer A, et al. Massive pulmonary embolism: surgical embolectomy versus thrombolytic therapy--should surgical indications be revisited? Eur J Cardiothorac Surg. 2013 Jan;43(1):90-4. DOI: https://doi.org/10.1093/ejcts/ezs123

Lee T, Itagaki S, Chiang YP, Egorova NN, Adams DH, Chikwe J. Survival and recurrence after acute pulmonary embolism treated with pulmonary embolectomy or thrombolysis in New York State, 1999 to 2013. J Thorac Cardiovasc Surg. 2018;155(3):1084-90. DOI: https://doi.org/10.1016/j.jtcvs.2017.07.074

Winters AA, McDaniel MJ, Binongo JN, et al. A comparison of surgical pulmonary embolectomy and catheter-directed lysis for life-threatening pulmonary emboli. Interact Cardiovasc Thorac Surg. 2020;30(3):388–93. DOI: https://doi.org/10.1093/icvts/ivz288

Keeling WB, Leshnower BG, Lasajanak Y, et al. Midterm benefits of surgical pulmonary embolectomy for acute pulmonary embolus on right ventricular function. J Thorac Cardiovasc Surg. 2016; 152(3):873–8. DOI: https://doi.org/10.1016/j.jtcvs.2015.11.042

Lattouf O, Leeper K, Kelli H. Life-threatening pulmonary embolism: a multidisciplinary approach to diagnosis and management. World J Cardiovasc Surg. 2013;3(6):190-197. DOI: https://doi.org/10.4236/wjcs.2013.36038

Keeling WB, Sundt T, Leacche M, et al. For the SPEAR working group. Outcomes after surgical pulmonary embolectomy for acute pulmonary embolus: a multi-institutional study. Ann Thorac Surg. 2016;102:1498–502. DOI: https://doi.org/10.1016/j.athoracsur.2016.05.004

Kearon C, Akl EA, Comerota AJ, et al. Antithrombotic therapy for VTE disease: antithrombotic therapy and prevention of thrombosis, 9th ed: american college of chest physicians evidence-based clinical practice guidelines. Chest. 2012;141(2):e419S-e96S. DOI: https://doi.org/10.1378/chest.11-2301

Fukuda I, Fukui K, Minakawa M, Koyama M, Ichinoseki I, Suzuki Y. Rescue surgical embolectomy for fatal pulmonary embolism in patient with intracranial hemorrhage. An of Ann Thorac Surg. 2006;81(2):735-7. DOI: https://doi.org/10.1016/j.athoracsur.2004.10.061

Neely RC, Byrne JG, Gosev I, Cohn LH, Javed Q, Rawn JD, et al. Surgical Embolectomy for Acute Massive and Submassive Pulmonary Embolism in a Series. Ann Thorac Surg. 2015;100(4):1245-52. DOI: https://doi.org/10.1016/j.athoracsur.2015.03.111

Lattouf OM, Laan D, Zapata D, Assaf EJ, Fallon J.J. Lessons learned on a new procedure: nonsternotomy minimally invasive pulmonary embolectomy. Card Surg. 2021;36(4):1258-1263. DOI: https://doi.org/10.1111/jocs.15357

Weinberg I, Kaufman J, Jaff MR. Inferior vena cava filters. JACC: Cardiovasc Interv. 2013;6(6):539-47. DOI: https://doi.org/10.1016/j.jcin.2013.03.006

Rosenberger P, Shernan SK, Rawn JD, Scott J, Eltzschig HK. Critical role of inferior vena caval filter placement after pulmonary embolectomy. J Card Surg. 2005;20(3):289-90. DOI: https://doi.org/10.1111/j.1540-8191.2005.200426.x

Stein PD, Matta F. Case fatality rate with pulmonary embolectomy for acute pulmonary embolism. Am J Med. 2012;125(5):471-7. DOI: https://doi.org/10.1016/j.amjmed.2011.12.003

Mismetti P, Laporte S, Pellerin O, et al. Effect of a retrievable inferior vena cava filter plus anticoagulation vs anticoagulation alone on risk of recurrent pulmonary embolism: a randomized clinical trial. JAMA. 2015;313(16):1627-35. DOI: https://doi.org/10.1001/jama.2015.3780

Stein PD, Matta F, Keyes DC, Willyerd GL. Impact of vena cava filters on in-hospital case fatality rate from pulmonary embolism. Am J Med. 2012;125(5):478-84. DOI: https://doi.org/10.1016/j.amjmed.2011.05.025

Isogai T, Yasunaga H, Matsui H, Tanaka H, Horiguchi H, Fushimi K. effectiveness of inferior vena cava filters on mortality as an adjuvant to antithrombotic therapy. Am J Med. 2015;128(3):312.e23-.e31. DOI: https://doi.org/10.1016/j.amjmed.2014.10.034

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2023-10-12

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Mdanat, E., Kabirpour, A., Sun, E., Alexis , S., Puskas, J., & Lattouf, O. (2023). State of the Art Management of Acute Pulmonary Embolism. JAP Academy Journal, 1(3). https://doi.org/10.58877/japaj.v1i3.72

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Review Articles